A weight-reduction plan excessive in n-3 polyunsaturated fatty acids (PUFAs) is related to a diminished threat for breast most cancers amongst ladies in China, in response to a research revealed on-line July 26 in Menopause.
Zhuo-Lin Zhang, M.D., from Solar Yat-sen College in Guangzhou, China, and colleagues examined the associations between breast most cancers threat and consumption of n-3 PUFAs in Chinese language ladies in a case-control research, together with 1,589 instances and 1,621 age-frequency-matched controls. A validated meals frequency questionnaire was used to evaluate dietary information.
The researchers noticed an affiliation for greater consumption of marine n-3 PUFAs and whole n-3 PUFAs with a decrease threat for breast most cancers, with adjusted odds ratios of 0.68 and 0.56 for quartile 4 versus 1, respectively. Inverse associations have been additionally seen for dietary alpha-linolenic acid, eicosapentaenoic acid, docosapentaenoic acid, and docosahexaenoic acid with breast most cancers threat, with adjusted odds ratios of 0.51, 0.68, 0.68, and 0.76, respectively. These inverse associations have been stronger for premenopausal ladies and girls with estrogen receptor (ER)-positive, progesterone receptor (PR)-positive, and ER-positive PR-positive tumors. In overweight/obese ladies, however not in ladies of regular weight, a diminished threat for breast most cancers was considerably related to rising n-3 PUFA consumption. A big interplay was seen for linoleic acid and marine n-3 PUFAs.
“This research highlights the impact of life-style habits and, particularly, dietary consumption of polyunsaturated fatty acids on breast most cancers threat,” Chrisandra Shufelt, M.D., president of the The North American Menopause Society, mentioned in a press release.
Zhuo-Lin Zhang et al, Affiliation of dietary consumption of n-3 polyunsaturated fatty acids with breast most cancers threat in pre- and postmenopausal Chinese language ladies, Menopause (2022). DOI: 10.1097/GME.0000000000001990
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