Dietary nitrate consumption is related to a decrease danger for development of age-related macular degeneration (AMD), in response to a examine printed on-line Dec. 22 in JAMA Ophthalmology.
Geoffrey Ok. Broadhead, M.D., Ph.D., from the Nationwide Eye Institute on the Nationwide Institutes of Well being in Bethesda, Maryland, and colleagues examined the affiliation between dietary nitrate consumption and AMD development utilizing information from the possible Age-Associated Eye Illness Examine (AREDS) and AREDS2 randomized medical trial cohorts and prolonged follow-up research. Information have been included for 7,788 contributors within the mixed AREDS/AREDS2 cohort, with 13,511 eligible eyes.
The researchers discovered that within the mixed AREDS/AREDS2 cohort, dietary nitrate consumption was related to a lowered danger for development to late AMD (hazard ratio, 0.77 for quartile 4 versus 1 of consumption); the dangers for geographic atrophy (GA) and neovascular AMD (nAMD) have been additionally lowered (hazard ratios, 0.71 and 0.85, respectively). Elevated nitrate consumption (quartile 4 versus 1) was related to a lowered danger for late AMD and GA (hazard ratios, 0.77 and 0.80, respectively), however not with nAMD in AREDS; no affiliation between nitrate consumption and late AMD or nAMD was seen in AREDS2. An affiliation was famous between Mediterranean dietary patterns and dietary nitrate consumption.
“These outcomes are from publish hoc analyses and are due to this fact hypothesis-generating in nature,” the authors write. “A lot of the result related to nitrate consumption might be attributed to plant-based dietary patterns usually, similar to a Mediterranean weight loss plan.”
Geoffrey Ok. Broadhead et al, Affiliation of Dietary Nitrate and a Mediterranean Weight-reduction plan With Age-Associated Macular Degeneration Amongst US Adults, JAMA Ophthalmology (2022). DOI: 10.1001/jamaophthalmol.2022.5404
Michael Larsen, Nitrates and Age-Associated Macular Degeneration, JAMA Ophthalmology (2022). DOI: 10.1001/jamaophthalmol.2022.5625
Copyright © 2022 HealthDay. All rights reserved.
Quotation:
Dietary nitrate consumption linked to decrease danger for AMD development (2022, December 28)
retrieved 29 December 2022
from https://medicalxpress.com/information/2022-12-dietary-nitrate-intake-linked-amd.html
This doc is topic to copyright. Aside from any truthful dealing for the aim of personal examine or analysis, no
half could also be reproduced with out the written permission. The content material is offered for data functions solely.
